Hermosillo got his start in professional soccer in 1984 as a forward with Club América, which he led to four league championships. He went on to play with a number of other Mexican teams, including Monterrey, Atlante and Guadalajara, and helped bring home league titles for Necaxa and Cruz Azul. He also starred on the field in Europe with Standard Liège (Belgium), and in the United States with the Los Angeles Galaxy. Since retiring from the field, Hermosillo has pursued a successful career as a sports commentator and served as Director of Mexico's National Commission of Physical Culture and Sports (CONADE). Hermosillo, who holds the record as the second top scorer in Mexican soccer history, is the latest addition to the soccer division of Deportes Telemundo, the unit of Telemundo Media that produces "Rumbo al Mundial," "Fútbol Estelar," "Fútbol Estelar León" and the Olympic Games.