Lindsay arrives in Mumbai after escaping from an Australian prison. He meets Prabhakar who takes him to his native village where he relaunches his criminal career as Shantaram in the city's notorious underworld.

Gifted psychiatric nurse Nik Katira is the most stable person at Wakefield mental health unit in the Blue Mountains of Australia. As his own sanity suddenly starts to slip, he finds himself questioning the line between reality and madness.