A year after the death of his friend and partner Sherlock Holmes, Dr. John Watson resumes his medical career at a clinic dedicated to the treatment of rare diseases. However, he soon finds that his old life is not done with him yet.

Hen and Junior farm a secluded piece of land that has been in Junior's family for generations, but their quiet life is thrown into turmoil when an uninvited stranger shows up at their door with a startling proposal.

A particle physicist grieving over the loss of her husband in a car crash travels to a parallel world to find him again, with dire consequences for her family.